GPCR catalog: 550 GPCRs and 400 figures

With our GPCR collection of 550 non-sensory GPCRs (300 human receptors and 250 mouse receptors) in native sequences, we provide functional assay for them in a single format, regardless of the subtypes of Gα proteins coupled. Click below for details or contact us for information about GPCRs of other animal species such as rats, rabbits, dogs, and macaque monkeys.

Species	Receptor	Family	Assays
Human	HTR1A 5-hydroxytryptamine receptor 1A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: serotonin EC50: 13 nM
Human	HTR1B 5-hydroxytryptamine receptor 1B	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Cardiology ⋅ à la carte	Reference agonist: serotonin EC50: 4.0 nM
Human	HTR1D 5-hydroxytryptamine receptor 1D	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 2.7 nM
Human	HTR1E 5-hydroxytryptamine receptor 1E	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 3.2 nM
Human	HTR1F 5-hydroxytryptamine receptor 1F	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 3.3 nM
Human	HTR2A 5-hydroxytryptamine receptor 2A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Respiratory ⋅ à la carte	Reference agonist: serotonin EC50: 1.9 nM
Human	HTR2B 5-hydroxytryptamine receptor 2B	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ Respiratory ⋅ à la carte	Reference agonist: serotonin EC50: 2.5 nM
Human	HTR2C 5-hydroxytryptamine receptor 2C	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: serotonin EC50: 1.7 nM
Human	HTR4 5-hydroxytryptamine receptor 4	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: serotonin EC50: 26 nM
Human	HTR5A 5-hydroxytryptamine receptor 5A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: serotonin EC50: 85 nM
Human	HTR6 5-hydroxytryptamine receptor 6	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: serotonin EC50: 8.6 nM
Human	HTR7 5-hydroxytryptamine receptor 7	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: serotonin EC50: 1.8 nM
Human	CHRM1 cholinergic receptor muscarinic 1	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: carbachol EC50: 310 nM
Human	CHRM2 cholinergic receptor muscarinic 2	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: carbachol EC50: 110 nM
Human	CHRM3 cholinergic receptor muscarinic 3	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: carbachol EC50: 31 nM
Human	CHRM4 cholinergic receptor muscarinic 4	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: carbachol EC50: 47 nM
Human	CHRM5 cholinergic receptor muscarinic 5	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: carbachol EC50: 5.9 nM
Human	ADORA1 adenosine A1 receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ Respiratory ⋅ à la carte	Reference agonist: NECA EC50: 4.8 nM
Human	ADORA2A adenosine A2a receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: NECA EC50: 11 nM
Human	ADORA2B adenosine A2b receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ à la carte	Reference agonist: NECA EC50: 19 nM
Human	ADORA3 adenosine A3 receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: NECA EC50: 1.6 nM
Human	ADRA1A adrenoceptor alpha 1A	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 18 nM
Human	ADRA1B adrenoceptor alpha 1B	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 28 nM
Human	ADRA1D adrenoceptor alpha 1D	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 67 nM
Human	ADRA2A adrenoceptor alpha 2A	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Cardiology ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: noradrenaline EC50: 71 nM
Human	ADRA2B adrenoceptor alpha 2B	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: noradrenaline EC50: 33 nM
Human	ADRA2C adrenoceptor alpha 2C	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: noradrenaline EC50: 89 nM
Human	ADRB1 adrenoceptor beta 1	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Cardiology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: isoproterenol EC50: 22 nM
Human	ADRB2 adrenoceptor beta 2	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: isoproterenol EC50: 26 nM
Human	ADRB3 adrenoceptor beta 3	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Cardiology ⋅ à la carte	Reference agonist: isoproterenol EC50: 47 nM
Human	AGTR1 angiotensin ⅠⅠ receptor type 1	Angiotensin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: angiotensin ⅠⅠ EC50: 920 pM
Human	APLNR apelin receptor	Apelin receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: apelin‐13 EC50: 8.1 nM
Human	GPBAR1 G protein-coupled bile acid receptor 1	Bile acid receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: TGR5 agonist EC50: 350 nM
Human	BRS3 bombesin receptor subtype 3	Bombesin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: bombesin EC50: 2.4 nM
Human	GRPR gastrin releasing peptide receptor	Bombesin receptors ⋅	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Psychiatry ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: GRP EC50: 1.3 nM
Human	NMBR neuromedin B receptor	Bombesin receptors ⋅	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Dermatology ⋅ à la carte	Reference agonist: NMB EC50: 590 pM
Human	CALCR calcitonin receptor	Calcitonin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: calcitonin EC50: 2.7 nM
Human	CALCRL calcitonin receptor like receptor	Calcitonin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: CGRP EC50: 1.0 nM
Human	CASR calcium sensing receptor	Calcium-sensing receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: cinacalcet EC50: 140 nM
Human	CNR1 cannabinoid receptor 1	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: Δ9‐THC EC50: 4.1 nM
Human	CNR2 cannabinoid receptor 2	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: -	Reference agonist: Δ9‐THC EC50: 11 nM
Human	GPR55 G protein-coupled receptor 55	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: LPI EC50: 1.2 µM
Human	GPR119 G protein-coupled receptor 119	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: N‐oleoylethanolamine EC50: 6.3 µM
Human	CMKLR1 chemerin chemokine-like receptor 1	Chemerin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: chemerin EC50: 15 nM
Human	CCR1 C-C motif chemokine receptor 1	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: CCL3 EC50: 250 pM
Human	CCR2 C-C motif chemokine receptor 2	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL2 EC50: 1.3 nM
Human	CCR4 C-C motif chemokine receptor 4	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ à la carte	Reference agonist: CCL22 EC50: 20 nM
Human	CCR5 C-C motif chemokine receptor 5	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL4 EC50: 7.1 nM
Human	CCR6 C-C motif chemokine receptor 6	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL20 EC50: 3.8 nM
Human	CCR7 C-C motif chemokine receptor 7	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: CCL21 EC50: 15 nM