感覚受容体を除くGPCRをヒト 300種、マウス 250種、計550種取り揃え、共役するGαタンパク質のサブタイプに依らず単一フォーマットのアッセイで活性を評価します。 各受容体の詳細は表をクリックしてください。また、ラット、ウサギ、イヌ、カニクイザルなど他種のGPCRについてはお問い合わせください。
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Species | Receptor | Family | Assays | |
|---|---|---|---|---|
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte |  Reference agonist: serotonin EC50: 13 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Cardiology ⋅ à la carte |  Reference agonist: serotonin EC50: 4.0 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: serotonin EC50: 2.7 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: serotonin EC50: 3.2 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: serotonin EC50: 3.3 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Respiratory ⋅ à la carte |  Reference agonist: serotonin EC50: 1.9 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ Respiratory ⋅ à la carte |  Reference agonist: serotonin EC50: 2.5 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |  Reference agonist: serotonin EC50: 1.7 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |  Reference agonist: serotonin EC50: 26 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |  Reference agonist: serotonin EC50: 85 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |  Reference agonist: serotonin EC50: 8.6 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ à la carte |  Reference agonist: serotonin EC50: 1.8 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |  Reference agonist: carbachol EC50: 310 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: carbachol EC50: 110 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: carbachol EC50: 31 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |  Reference agonist: carbachol EC50: 47 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |  Reference agonist: carbachol EC50: 5.9 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ Respiratory ⋅ à la carte |  Reference agonist: NECA EC50: 4.8 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |  Reference agonist: NECA EC50: 11 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ à la carte |  Reference agonist: NECA EC50: 19 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte |  Reference agonist: NECA EC50: 1.6 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: L‐phenylephrine EC50: 18 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ à la carte |  Reference agonist: L‐phenylephrine EC50: 28 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: L‐phenylephrine EC50: 67 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Cardiology ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |  Reference agonist: noradrenaline EC50: 71 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: noradrenaline EC50: 33 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |  Reference agonist: noradrenaline EC50: 89 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Cardiology ⋅ Gastrointestinal ⋅ à la carte |  Reference agonist: isoproterenol EC50: 22 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: isoproterenol EC50: 26 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Cardiology ⋅ à la carte |  Reference agonist: isoproterenol EC50: 47 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: angiotensin ⅠⅠ EC50: 920 pM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |  Reference agonist: apelin‐13 EC50: 8.1 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte |  Reference agonist: TGR5 agonist EC50: 350 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: bombesin EC50: 2.4 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Psychiatry ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: GRP EC50: 1.3 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Dermatology ⋅ à la carte |  Reference agonist: NMB EC50: 590 pM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: calcitonin EC50: 2.7 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: CGRP EC50: 1.0 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: cinacalcet EC50: 140 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: Δ9‐THC EC50: 4.1 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: - |  Reference agonist: Δ9‐THC EC50: 11 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: LPI EC50: 1.2 µM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte |  Reference agonist: N‐oleoylethanolamine EC50: 6.3 µM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: chemerin EC50: 15 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |  Reference agonist: CCL3 EC50: 250 pM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: CCL2 EC50: 1.3 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ à la carte |  Reference agonist: CCL22 EC50: 20 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: CCL4 EC50: 7.1 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |  Reference agonist: CCL20 EC50: 3.8 nM | ||
Human | Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |  Reference agonist: CCL21 EC50: 15 nM |
