5-HT5 Receptors
Overview
Two genes have been identified that give rise to 5-ht5a and 5-ht5b proteins with structures consistent with GPCRs although in humans the 5-ht5b gene is a pseudogene since a stop codon has evolved that would, if expressed, result in a truncated protein devoid of key functional moieties of the receptor. The predicted protein sequences display less than 38% amino acid sequence identity to other 5-HT GPCRs, thus clearly distinguishing the 5-ht5a protein from other 5-HT receptors.5-ht5a is yet to receive receptor status since no robust response signal in native tissue has been described. Native 5-ht5a protein would appear G-protein coupled and recombinant expression allows coupling via various transduction systems including the G-protein mediated inhibition of adenylate cyclase. A selective antagonist based on recombinant protein function has been identified (SB699551-A).Excerpt from IUPHAR/BPS Guide to Pharmacology Filters Sort resultsReset ApplyFilters Sort resultsReset Apply
Species Receptor Family Assays Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅Psychiatry⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la cartePAGE TOP