Angiotensin receptors

Overview

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors, which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, telmisartan, etc. are clinically used AT1 receptor blockers.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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Concentration-response curve for AGTR1
Reference agonist:
angiotensin ⅠⅠ
EC50:
920 pM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
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Mouse non-orphan GPCRs
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Reference agonist:
angiotensin ⅠⅠ
EC50:
1.1 nM