Human CASR

Figure. Concentration-dependent activation of CASR by cinacalcet

Reporter cells were transfected with either the expression plasmid for human calcium sensing receptor (CASR) or the mock plasmid and treated with various concentrations of cinacalcet. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 140 nM.

説明

Nomenclature: calcium sensing receptor
Available assay modes: Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels: à la carte, Immunology/Infection, Oncology, Hematology, Endocrinology/Metabolism, Ophthalmology, Cardiology, Respiratory, Gastrointestinal, Dermatology, Musculoskeletal, Urology/Reproduction, Human non-orphan GPCRs

CASR orthologs in other animal species including rat, rabbit, dog, and macaque monkey are ready upon request.

Related Receptors


Human	CASR calcium sensing receptor
Mouse	Casr calcium-sensing receptor

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