GABBR1-GABBR2

Assay services
Available
Assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
HGNC symbol
GABBR1-GABBR2
HGNC name
gamma-aminobutyric acid type B receptor subunits 1/2
Family
GABAB receptors
Species
Human
Guide to Pharmacology link
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=240
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Description

Figure. Concentration-dependent activation of GABBR1-GABBR2 by baclofen. Reporter cells were transfected with either the expression plasmid for gamma-amino­butyric acid type B receptor subunit 1 (GABBR1-GABBR2) or the mock plasmid and treated with various concentrations of baclofen. Data points shown are the mean ± SEM of an experiment performed in triplicate, and the curve is a fit to Hill equation with an EC50 of 9.4 µM.