Human MCHR1

Figure. Concentration-dependent activation of MCHR1 by MCH

Reporter cells were transfected with either the expression plasmid for human melanin concentrating hormone receptor 1 (MCHR1) or the mock plasmid and treated with various concentrations of MCH. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 37 nM.

melanin concentrating hormone receptor 1
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Human non-orphan GPCRs

Melanin-concentrating hormone receptors

Melanin-concentrating hormone (MCH) receptors are activated by an endogenous nonadecameric cyclic peptide identical in humans and rats (DFDMLRCMLGRVYRPCWQV; mammalian MCH) generated from a precursor (PMCH, P20382), which also produces neuropeptide EI and neuropeptide GE.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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