Figure. Concentration-dependent activation of F2RL2 by PAR-3. Reporter cells were transfected with either the expression plasmid for co­ag­u­la­tion factor II throm­bin receptor like 2 (F2RL2) or the mock plasmid and treated with various concentrations of PAR-3. Data points shown are the mean ± SEM of an experiment performed in triplicate, and the curve is a fit to Hill equation with an EC50 of 9.2 µM.