arginine vasopressin receptor 1B (AVPR1B)

Human AVPR1B

Figure. Concentration-dependent activation of AVPR1B by [R]‐vasopressin

Reporter cells were transfected with either the expression plasmid for human arginine vasopressin receptor 1B (AVPR1B) or the mock plasmid and treated with various concentrations of [R]‐vasopressin. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 840 pM.

Description

Nomenclature: arginine vasopressin receptor 1B
Available assay modes: Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels: à la carte, Human non-orphan GPCRs

Vasopressin and oxytocin receptors
Vasopressin (AVP) and oxytocin (OT) receptors are activated by the endogenous cyclic nonapeptides vasopressin and oxytocin. These peptides are derived from precursors which also produce neurophysins (neurophysin I for... [read more] oxytocin; neurophysin II for vasopressin). Vasopressin and oxytocin differ at only 2 amino acids (positions 3 and 8). There are metabolites of these neuropeptides that may be biologically active [1].
Reference
de Wied D, Diamant M, Fodor M. Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocrinol 1993;14:251-302.
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Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors


Human	AVPR1A arginine vasopressin receptor 1A
Human	AVPR1B arginine vasopressin receptor 1B
Human	AVPR2 arginine vasopressin receptor 2
Human	OXTR oxytocin receptor
Mouse	Avpr1a arginine vasopressin receptor 1A
Mouse	Avpr1b arginine vasopressin receptor 1B
Mouse	Avpr2 arginine vasopressin receptor 2
Mouse	Oxtr oxytocin receptor