Kisspeptin receptor

Overview

The kisspeptin receptor, like neuropeptide FF (NPFF), prolactin-releasing peptide (PrP) and QRFP receptors (provisional nomenclature) responds to endogenous peptides with an arginine-phenylalanine-amide (RFamide) motif. kisspeptin-54 (KP54, originally named metastin), kisspeptin-13 (KP13) and kisspeptin-10 (KP10) are biologically-active peptides cleaved from the KISS1 (Q15726) gene product. Kisspeptins have roles in, for example, cancer metastasis, fertility/puberty regulation and glucose homeostasis.
Excerpt from IUPHAR/BPS Guide to Pharmacology
Filters Sort results
Reset Apply
Species
Family
Panel
Download Catalog
Filters Sort results
Reset Apply
Species
Receptor
Family
Assays
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Oncology
Endocrinology/Metabolism
Neurology
Ophthalmology
Gastrointestinal
Dermatology
Musculoskeletal
Urology/Reproduction
à la carte
Reference agonist:
kisspeptin‐10
EC50:
1.3 nM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
kisspeptin‐10
EC50:
4.2 nM