Prokineticin receptors, PKR1 and PKR2 respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, ) is a potent, non-selective agonist at prokineticin receptors , while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., ), is equipotent at recombinant PKR1 and PKR2 , and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.
Schweitz H, Pacaud P, Diochot S, et al. MIT(1), a black mamba toxin with a new and highly potent activity on intestinal contraction. FEBS Lett 1999;461:183-8.
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