Overview

Thyrotropin-releasing hormone (TRH) receptors are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH₁ and TRH₂ receptors [1]. [³H]TRH (human, mouse, rat) is... [read more] able to label both TRH₁ and TRH₂ receptors with K_d values of 13 and 9 nM respectively. Synthesis and biology of ring-modified L-Histidine containing TRH analogues has been reported [2].

References

1. Sun Y, Lu X, Gershengorn MC. Thyrotropin-releasing hormone receptors -- similarities and differences. J Mol Endocrinol 2003;30:87-97.
2. Meena CL, Thakur A, Nandekar PP, et al. Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. Eur J Med Chem 2016;111:72-83.

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