Vasopressin and oxytocin receptors

Overview

Vasopressin (AVP) and oxytocin (OT) receptors are activated by the endogenous cyclic nonapeptides vasopressin and oxytocin. These peptides are derived from precursors which also produce neurophysins (neurophysin I for oxytocin; neurophysin II for vasopressin). Vasopressin and oxytocin differ at only 2 amino acids (positions 3 and 8). There are metabolites of these neuropeptides that may be biologically active [1].

Reference

  1. de Wied D, Diamant M, Fodor M. Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocrinol 1993;14:251-302.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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Human
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Assay modes:
Agonist
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Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Psychiatry
Cardiology
Urology/Reproduction
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
510 pM
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
840 pM
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Endocrinology/Metabolism
Cardiology
Musculoskeletal
Urology/Reproduction
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
4.8 nM
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Psychiatry
Respiratory
à la carte
Reference agonist:
oxytocin
EC50:
1.9 nM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
1.7 nM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
[R]‐vasopressin
EC50:
410 pM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
oxytocin
EC50:
510 pM