Melanocortin receptors
Overview
Melanocortin receptors are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.Excerpt from IUPHAR/BPS Guide to Pharmacology Filters Sort resultsReset Apply
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Species Receptor Family Assays Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅Oncology⋅Endocrinology/Metabolism⋅Neurology⋅Ophthalmology⋅Dermatology⋅Musculoskeletal⋅à la carte Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅Immunology/Infection⋅Endocrinology/Metabolism⋅Musculoskeletal⋅Urology/Reproduction⋅à la carte Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅à la carte Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅Endocrinology/Metabolism⋅à la carte Human AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Human non-orphan GPCRs⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la carte Mouse AvailableAssay modes:Agonist⋅Inverse agonist⋅Antagonist⋅PAM⋅NAMPanels:Mouse non-orphan GPCRs⋅à la cartePAGE TOP