- melanocortin 1 receptor
- Available assay modes
- Agonist, Inverse agonist, Antagonist, PAM, NAM
- à la carte, Oncology, Endocrinology/Metabolism, Neurology, Ophthalmology, Dermatology, Musculoskeletal, Human non-orphan GPCRs
Melanocortin receptorsMelanocortin receptors are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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