Mouse Mc2r

Figure. Concentration-dependent activation of Mc2r by ACTH

Reporter cells were transfected with either the expression plasmid for mouse melanocortin 2 receptor (Mc2r) or the mock plasmid and treated with various concentrations of the reference agonist. Data points shown are the mean ± SEM of an experiment (n = 4).

Nomenclature
melanocortin 2 receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
à la carte, Mouse non-orphan GPCRs

Melanocortin receptors

Melanocortin receptors are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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Human
MC1R
melanocortin 1 receptor
Human
MC2R
melanocortin 2 receptor
Human
MC3R
melanocortin 3 receptor
Human
MC4R
melanocortin 4 receptor
Human
MC5R
melanocortin 5 receptor
Mouse
Mc1r
melanocortin 1 receptor
Mouse
Mc2r
melanocortin 2 receptor
Mouse
Mc3r
melanocortin 3 receptor
Mouse
Mc4r
melanocortin 4 receptor
Mouse
Mc5r
melanocortin 5 receptor