感覚受容体を除くGPCRをヒト 300種、マウス 250種、計550種取り揃え、共役するGαタンパク質のサブタイプに依らず単一フォーマットのアッセイで活性を評価します。 各受容体の詳細は表をクリックしてください。
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Species
| Receptor
| Family
| Assays | |
|---|---|---|---|---|
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte |
 Reference agonist: serotonin EC50:
13 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Cardiology ⋅ à la carte |
 Reference agonist: serotonin EC50:
4.0 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: serotonin EC50:
2.7 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: serotonin EC50:
3.2 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: serotonin EC50:
3.3 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Respiratory ⋅ à la carte |
 Reference agonist: serotonin EC50:
1.9 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Cardiology ⋅ Respiratory ⋅ à la carte |
 Reference agonist: serotonin EC50:
2.5 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |
 Reference agonist: serotonin EC50:
1.7 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |
 Reference agonist: serotonin EC50:
26 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |
 Reference agonist: serotonin EC50:
85 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |
 Reference agonist: serotonin EC50:
8.6 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ à la carte |
 Reference agonist: serotonin EC50:
1.8 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |
 Reference agonist: carbachol EC50:
310 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: carbachol EC50:
110 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: carbachol EC50:
31 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte |
 Reference agonist: carbachol EC50:
47 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte |
 Reference agonist: carbachol EC50:
5.9 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ Respiratory ⋅ à la carte |
 Reference agonist: NECA EC50:
4.8 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |
 Reference agonist: NECA EC50:
11 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ à la carte |
 Reference agonist: NECA EC50:
19 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte |
 Reference agonist: NECA EC50:
1.6 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: L‐phenylephrine EC50:
18 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ à la carte |
 Reference agonist: L‐phenylephrine EC50:
28 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: L‐phenylephrine EC50:
67 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Psychiatry ⋅ Cardiology ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |
 Reference agonist: noradrenaline EC50:
71 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: noradrenaline EC50:
33 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |
 Reference agonist: noradrenaline EC50:
89 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Cardiology ⋅ Gastrointestinal ⋅ à la carte |
 Reference agonist: isoproterenol EC50:
22 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: isoproterenol EC50:
26 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Cardiology ⋅ à la carte |
 Reference agonist: isoproterenol EC50:
47 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: angiotensin ⅠⅠ EC50:
920 pM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte |
 Reference agonist: apelin‐13 EC50:
8.1 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte |
 Reference agonist: TGR5 agonist EC50:
350 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: bombesin EC50:
2.4 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Oncology ⋅ Psychiatry ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: GRP EC50:
1.3 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Oncology ⋅ Dermatology ⋅ à la carte |
 Reference agonist: NMB EC50:
590 pM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: calcitonin EC50:
2.7 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: CGRP EC50:
1.0 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: cinacalcet EC50:
140 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: Δ9‐THC EC50:
4.1 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
- |
 Reference agonist: Δ9‐THC EC50:
11 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: LPI EC50:
1.2 µM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ à la carte |
 Reference agonist: N‐oleoylethanolamine EC50:
6.3 µM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: chemerin EC50:
15 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |
 Reference agonist: CCL3 EC50:
250 pM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: CCL2 EC50:
1.3 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ à la carte |
 Reference agonist: CCL22 EC50:
20 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: CCL4 EC50:
7.1 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte |
 Reference agonist: CCL20 EC50:
3.8 nM |
||
Human |
Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:
Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte |
 Reference agonist: CCL21 EC50:
15 nM |
