cholinergic receptor muscarinic 4 (CHRM4)

Human CHRM4

Figure. Concentration-dependent activation of CHRM4 by carbachol

Reporter cells were transfected with either the expression plasmid for human cholinergic receptor muscarinic 4 (CHRM4) or the mock plasmid and treated with various concentrations of carbachol. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 47 nM.

Description

Nomenclature: cholinergic receptor muscarinic 4
Available assay modes: Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels: à la carte, Psychiatry, Neurology, Human non-orphan GPCRs

Acetylcholine receptors (muscarinic)
Muscarinic acetylcholine receptors (mAChRs) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for... [read more] many disorders. Functionally, M₁, M₃, and M₅ mAChRs preferentially couple to G_q/11 proteins, whilst M₂ and M₄ mAChRs predominantly couple to G_i/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates. [close]

Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors


Human	CHRM1 cholinergic receptor muscarinic 1
Human	CHRM2 cholinergic receptor muscarinic 2
Human	CHRM3 cholinergic receptor muscarinic 3
Human	CHRM4 cholinergic receptor muscarinic 4
Human	CHRM5 cholinergic receptor muscarinic 5
Mouse	Chrm1 cholinergic receptor, muscarinic 1, CNS
Mouse	Chrm2 cholinergic receptor, muscarinic 2, cardiac
Mouse	Chrm3 cholinergic receptor, muscarinic 3, cardiac
Mouse	Chrm4 cholinergic receptor, muscarinic 4
Mouse	Chrm5 cholinergic receptor, muscarinic 5