Human CHRM4

Figure. Concentration-dependent activation of CHRM4 by carbachol

Reporter cells were transfected with either the expression plasmid for human cholinergic receptor muscarinic 4 (CHRM4) or the mock plasmid and treated with various concentrations of carbachol. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 47 nM.

cholinergic receptor muscarinic 4
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Psychiatry, Neurology, Human non-orphan GPCRs

Acetylcholine receptors (muscarinic)

Muscarinic acetylcholine receptors (mAChRs) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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