Mouse Chrm1

Figure. Concentration-dependent activation of Chrm1 by carbachol

Reporter cells were transfected with either the expression plasmid for mouse cholinergic receptor, muscarinic 1, CNS (Chrm1) or the mock plasmid and treated with various concentrations of the reference agonist. Data points shown are the mean ± SEM of an experiment (n = 4).

cholinergic receptor, muscarinic 1, CNS
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Mouse non-orphan GPCRs

Acetylcholine receptors (muscarinic)

Muscarinic acetylcholine receptors (mAChRs) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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