GPBAR1

Figure. Concentration-dependent activation of GPBAR1 by TGR5 agonist
Reporter cells were transfected with either the expression plasmid for G protein-coupled bile acid receptor 1 (GPBAR1) or the mock plasmid and treated with various concentrations of TGR5 agonist. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 350 nM.
Assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
Gastrointestinal, Non-orphan GPCRs
Symbol
GPBAR1
Nomenclature
G protein-coupled bile acid receptor 1
Family
Species
Human