GPCR catalog: 550 GPCRs and 400 figures

With our GPCR collection of 550 non-sensory GPCRs (300 human receptors and 250 mouse receptors) in native sequences, we provide functional assay for them in a single format, regardless of the subtypes of Gα proteins coupled. Click below for details.

Species	Receptor	Family	Assays
Human	HTR1A 5-hydroxytryptamine receptor 1A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: serotonin EC50: 13 nM
Human	HTR1B 5-hydroxytryptamine receptor 1B	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Cardiology ⋅ à la carte	Reference agonist: serotonin EC50: 4.0 nM
Human	HTR1D 5-hydroxytryptamine receptor 1D	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 2.7 nM
Human	HTR1E 5-hydroxytryptamine receptor 1E	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 3.2 nM
Human	HTR1F 5-hydroxytryptamine receptor 1F	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: serotonin EC50: 3.3 nM
Human	HTR2A 5-hydroxytryptamine receptor 2A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Respiratory ⋅ à la carte	Reference agonist: serotonin EC50: 1.9 nM
Human	HTR2B 5-hydroxytryptamine receptor 2B	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ Respiratory ⋅ à la carte	Reference agonist: serotonin EC50: 2.5 nM
Human	HTR2C 5-hydroxytryptamine receptor 2C	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: serotonin EC50: 1.7 nM
Human	HTR4 5-hydroxytryptamine receptor 4	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: serotonin EC50: 26 nM
Human	HTR5A 5-hydroxytryptamine receptor 5A	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: serotonin EC50: 85 nM
Human	HTR6 5-hydroxytryptamine receptor 6	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: serotonin EC50: 8.6 nM
Human	HTR7 5-hydroxytryptamine receptor 7	5-Hydroxytryptamine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: serotonin EC50: 1.8 nM
Human	CHRM1 cholinergic receptor muscarinic 1	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: carbachol EC50: 310 nM
Human	CHRM2 cholinergic receptor muscarinic 2	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: carbachol EC50: 110 nM
Human	CHRM3 cholinergic receptor muscarinic 3	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: carbachol EC50: 31 nM
Human	CHRM4 cholinergic receptor muscarinic 4	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Neurology ⋅ à la carte	Reference agonist: carbachol EC50: 47 nM
Human	CHRM5 cholinergic receptor muscarinic 5	Acetylcholine receptors (muscarinic)	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ à la carte	Reference agonist: carbachol EC50: 5.9 nM
Human	ADORA1 adenosine A1 receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ Respiratory ⋅ à la carte	Reference agonist: NECA EC50: 4.8 nM
Human	ADORA2A adenosine A2a receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: NECA EC50: 11 nM
Human	ADORA2B adenosine A2b receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ à la carte	Reference agonist: NECA EC50: 19 nM
Human	ADORA3 adenosine A3 receptor	Adenosine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: NECA EC50: 1.6 nM
Human	ADRA1A adrenoceptor alpha 1A	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 18 nM
Human	ADRA1B adrenoceptor alpha 1B	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Cardiology ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 28 nM
Human	ADRA1D adrenoceptor alpha 1D	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: L‐phenylephrine EC50: 67 nM
Human	ADRA2A adrenoceptor alpha 2A	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Psychiatry ⋅ Cardiology ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: noradrenaline EC50: 71 nM
Human	ADRA2B adrenoceptor alpha 2B	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: noradrenaline EC50: 33 nM
Human	ADRA2C adrenoceptor alpha 2C	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: noradrenaline EC50: 89 nM
Human	ADRB1 adrenoceptor beta 1	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Cardiology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: isoproterenol EC50: 22 nM
Human	ADRB2 adrenoceptor beta 2	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: isoproterenol EC50: 26 nM
Human	ADRB3 adrenoceptor beta 3	Adrenoceptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Endocrinology/Metabolism ⋅ Cardiology ⋅ à la carte	Reference agonist: isoproterenol EC50: 47 nM
Human	AGTR1 angiotensin ⅠⅠ receptor type 1	Angiotensin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: angiotensin ⅠⅠ EC50: 920 pM
Human	APLNR apelin receptor	Apelin receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Cardiology ⋅ à la carte	Reference agonist: apelin‐13 EC50: 8.1 nM
Human	GPBAR1 G protein-coupled bile acid receptor 1	Bile acid receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: TGR5 agonist EC50: 350 nM
Human	BRS3 bombesin receptor subtype 3	Bombesin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: bombesin EC50: 2.4 nM
Human	GRPR gastrin releasing peptide receptor	Bombesin receptors ⋅	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Psychiatry ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: GRP EC50: 1.3 nM
Human	NMBR neuromedin B receptor	Bombesin receptors ⋅	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Dermatology ⋅ à la carte	Reference agonist: NMB EC50: 590 pM
Human	CALCR calcitonin receptor	Calcitonin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: calcitonin EC50: 2.7 nM
Human	CALCRL calcitonin receptor like receptor	Calcitonin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: CGRP EC50: 1.0 nM
Human	CASR calcium sensing receptor	Calcium-sensing receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: cinacalcet EC50: 140 nM
Human	CNR1 cannabinoid receptor 1	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: Δ9‐THC EC50: 4.1 nM
Human	CNR2 cannabinoid receptor 2	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: -	Reference agonist: Δ9‐THC EC50: 11 nM
Human	GPR55 G protein-coupled receptor 55	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: LPI EC50: 1.2 µM
Human	GPR119 G protein-coupled receptor 119	Cannabinoid receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: N‐oleoylethanolamine EC50: 6.3 µM
Human	CMKLR1 chemerin chemokine-like receptor 1	Chemerin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: chemerin EC50: 15 nM
Human	CCR1 C-C motif chemokine receptor 1	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: CCL3 EC50: 250 pM
Human	CCR2 C-C motif chemokine receptor 2	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL2 EC50: 1.3 nM
Human	CCR4 C-C motif chemokine receptor 4	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ à la carte	Reference agonist: CCL22 EC50: 20 nM
Human	CCR5 C-C motif chemokine receptor 5	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL4 EC50: 7.1 nM
Human	CCR6 C-C motif chemokine receptor 6	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CCL20 EC50: 3.8 nM
Human	CCR7 C-C motif chemokine receptor 7	Chemokine receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ à la carte	Reference agonist: CCL21 EC50: 15 nM