drugs

GPCR ranking: Number of receptor-targeted drugs

All GPCRs are not made equal. As illustrated in "About GPCR," some GPCRs have dozens of drugs targeting them while the majority of GPCRs have few or none in the market, clinical trials, or labs. Based on a GPCR drug database [1,2], the figure above and the table below rank GPCRs in ascending and descending order, respectively, of the number of receptor-targeted drugs. The distribution is obviously skewed. N.B., there are also ~150 nonsensory GPCRs missing in the table since they have never been addressed as therapeutic targets. Some drug-receptor pairs have multiple statuses/phases like Approved and Phase 3 in the database [1]. In such cases, the most advanced status […]