- galanin receptor 1
- Available assay modes
- Agonist, Inverse agonist, Antagonist, PAM, NAM
- à la carte, Human non-orphan GPCRs
Galanin receptorsGalanin receptors are activated by the endogenous peptides galanin and galanin-like peptide. Human galanin is a 30 amino-acid non-amidated peptide ; in other species, it is 29 amino acids long and C-terminally amidated. Amino acids 1-14 of galanin are highly conserved in mammals, birds, reptiles, amphibia and fish. Shorter peptide species (e.g. human galanin-1-19  and porcine galanin-5-29 ) and N-terminally extended forms (e.g. N-terminally seven and nine residue elongated forms of porcine galanin [3,4]) have been reported. More recently, the newly-identified peptide, spexin (SPX), has been reported to activate human GAL2 and GAL3 (but not GAL1) receptors in heterologous expression systems; and to alter GAL2/3 receptor-related behaviours in animals .
- Evans HF, Shine J. Human galanin: molecular cloning reveals a unique structure. Endocrinology 1991;129:1682-4.
- Bersani M, Johnsen AH, Højrup P, et al. Human galanin: primary structure and identification of two molecular forms. FEBS Lett 1991;283:189-94.
- Sillard R, Rökaeus A, Xu Y, et al. Variant forms of galanin isolated from porcine brain. Peptides 1992;13:1055-60.
- Bersani M, Thim L, Rasmussen TN, et al. Galanin and galanin extended at the N-terminus with seven and nine amino acids are produced in and secreted from the porcine adrenal medulla in almost equal amounts. Endocrinology 1991;129:2693-8.
- Kim DK, Yun S, Son GH, et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 2014;155:1864-73.