Human NTSR1

Figure. Concentration-dependent activation of NTSR1 by neurotensin

Reporter cells were transfected with either the expression plasmid for human neurotensin receptor 1 (NTSR1) or the mock plasmid and treated with various concentrations of neurotensin. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 180 pM.

Nomenclature
neurotensin receptor 1
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
à la carte, Oncology, Psychiatry, Human non-orphan GPCRs

Neurotensin receptors

Neurotensin receptors are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1-0.3 and 3-5 nM concentrations respectively.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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Human
NTSR1
neurotensin receptor 1
Human
NTSR2
neurotensin receptor 2
Mouse
Ntsr1
neurotensin receptor 1
Mouse
Ntsr2
neurotensin receptor 2