Human SUCNR1

Figure. Concentration-dependent activation of SUCNR1 by succinic acid

Reporter cells were transfected with either the expression plasmid for human succinate receptor 1 (SUCNR1) or the mock plasmid and treated with various concentrations of succinic acid. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 14 µM.

Nomenclature
succinate receptor 1
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
à la carte, Ophthalmology, Human non-orphan GPCRs

Succinate receptor

The Succinate receptor was identified as being activated by physiological levels of the Kreb's cycle intermediate succinate and other dicarboxylic acids such as maleate in 2004. Since its pairing with its endogenous ligand, the receptor has been the focus of intensive research and its role has been evidenced in various (patho)physiological processes such as regulation of renin production, retinal angiogenesis, inflammation or the immune response.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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Human
SUCNR1
succinate receptor 1
Mouse
Sucnr1
succinate receptor 1