Mini Audio Guide
This 12-minute audio briefing offers a clear, accessible overview of Tanso Biosciences’ capabilities and services—designed to help you understand how we support GPCR drug discovery from screening to validation. Now available on Apple Podcasts, Spotify, and YouTube.
Reproducibility of Tanso Biosciences' GPCR Assay
Reproducibility is key when it comes to pharmaceutical research. Tanso Biosciences' GPCR functional assay is not only sensitive and versatile but highly reproducible. We have conducted a series of experiments to verify the consistency of our assay, and the results are impressive. We performed concentration-response analyses for β1 adrenoceptor (ADRB1) vs. isoproterenol on three different days (Figure 1, Table 1). Each test yielded a very close EC50 value, indicating excellent reproducibility of the assay. We examined the variability between experimenters. Two experimenters in our lab conducted concentration-response analyses for type 1 angiotensin 2 receptor (AGTR1) and yielded comparable results both in the agonist mode (Figure 2, Table 2) and the […]
Disease-Associated GPCR Variants
The table below lists GPCR variants associated with pathological conditions. NCBI ClinVar was searched for the receptors in the GPCR Catalog with the parameter for clinical significance as 'pathological,' "likely pathological," and "drug response." Update – June 13, 2022. All the 415 GPCRs in IUPHAR/BPS Guide to Pharmacology were searched for. Retrieved June 13, 2022, from https://www.ncbi.nlm.nih.gov/clinvar/