Human MTNR1A

Figure. Concentration-dependent activation of MTNR1A by melatonin

Reporter cells were transfected with either the expression plasmid for human melatonin receptor 1A (MTNR1A) or the mock plasmid and treated with various concentrations of melatonin. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 100 pM.

melatonin receptor 1A
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Ophthalmology, Human non-orphan GPCRs

Melatonin receptors

Melatonin receptors are activated by the endogenous ligands melatonin and clinically used drugs like ramelteon, agomelatine and tasimelteon.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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