Human NPY1R

Figure. Concentration-dependent activation of NPY1R by NPY

Reporter cells were transfected with either the expression plasmid for human neuropeptide Y receptor Y1 (NPY1R) or the mock plasmid and treated with various concentrations of NPY. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 840 pM.

neuropeptide Y receptor Y1
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Endocrinology/Metabolism, Psychiatry, Neurology, Human non-orphan GPCRs

Neuropeptide Y receptors

Neuropeptide Y (NPY) receptors are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified as the Y3 receptor has been identified as the CXCR4 chemokine recepter (originally named LESTR, [1]). The y6 receptor is a functional gene product in mouse, absent in rat, but contains a frame-shift mutation in primates producing a truncated non-functional gene [2]. Many of the agonists exhibit differing degrees of selectivity dependent on the species examined. For example, the potency of PP is greater at the rat Y4 receptor than at the human receptor [3]. In addition, many agonists lack selectivity for individual subtypes, but can exhibit comparable potency against pairs of NPY receptor subtypes, or have not been examined for activity at all subtypes. [125I]-PYY or [125I]-NPY can be used to label Y1, Y2, Y5 and y6 subtypes non-selectively, while [125I,cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP may be used to label Y5 receptors preferentially (note that cPP denotes chicken peptide sequence and hPP is the human sequence).


  1. Loetscher M, Geiser T, O'Reilly T, et al. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 1994;269:232-7.
  2. Gregor P, Millham ML, Feng Y, et al. Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett 1996;381:58-62.
  3. Eriksson H, Berglund MM, Holmberg SK, et al. The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4. Regul Pept 1998;75-76:29-37.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

Filters Sort results
Reset Apply