Human QRFPR

Figure. Concentration-dependent activation of QRFPR by QRFP

Reporter cells were transfected with either the expression plasmid for human pyroglutamylated RFamide peptide receptor (QRFPR) or the mock plasmid and treated with various concentrations of QRFP. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 720 pM.

Nomenclature
pyroglutamylated RFamide peptide receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
à la carte, Human non-orphan GPCRs

QRFP receptor

The human gene encoding the QRFP receptor (QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al. from a hypothalamus cDNA library [1]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y2 (37%) and galanin Gal1 (35%) receptors.

Reference

  1. Lee DK, Nguyen T, Lynch KR, et al. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 2001;275:83-91.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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Human
QRFPR
pyroglutamylated RFamide peptide receptor
Mouse
Qrfpr
pyroglutamylated RFamide peptide receptor