Human SSTR1

Figure. Concentration-dependent activation of SSTR1 by somatostatin‐14

Reporter cells were transfected with either the expression plasmid for human somatostatin receptor 1 (SSTR1) or the mock plasmid and treated with various concentrations of somatostatin‐14. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 23 nM.

somatostatin receptor 1
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
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Somatostatin receptors

Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [1]). Activation of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14) and somatostatin-28 (SRIF-28). cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [2].


  1. Günther T, Tulipano G, Dournaud P, et al. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev 2018;70:763-835.
  2. de Lecea L, Criado JR, Prospero-Garcia O, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 1996;381:242-5.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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