- tachykinin receptor 3
- Available assay modes
- Agonist, Inverse agonist, Antagonist, PAM, NAM
- à la carte, Endocrinology/Metabolism, Neurology, Ophthalmology, Musculoskeletal, Urology/Reproduction, Human non-orphan GPCRs
Tachykinin receptorsTachykinin receptors are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previously known as neurokinin β, neuromedin K), neuropeptide K and neuropeptide γ (N-terminally extended forms of neurokinin A). The neurokinins (A and B) are mammalian members of the tachykinin family, which includes peptides of mammalian and nonmammalian origin containing the consensus sequence: Phe-x-Gly-Leu-Met. Marked species differences in in vitro pharmacology exist for all three receptors, in the context of nonpeptide ligands. Antagonists such as aprepitant and fosaprepitant were approved by FDA and EMA, in combination with other antiemetic agents, for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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