Figure. Concentration-dependent activation of LHCGR by rLHα/β

Reporter cells were transfected with either the expression plasmid for human luteinizing hormone/choriogonadotropin receptor (LHCGR) or the mock plasmid and treated with various concentrations of rLHα/β. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 26 ng/ml.

luteinizing hormone/choriogonadotropin receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
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Glycoprotein hormone receptors

Glycoprotein hormone receptors are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [1,2].


  1. Sairam MR. Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J 1989;3:1915-26.
  2. Davidson JS, Assefa D, Pawson A, et al. Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment. Biochemistry 1997;36:12881-9.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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