Mouse Fshr

Figure. Concentration-dependent activation of Fshr by FSH

Reporter cells were transfected with either the expression plasmid for mouse follicle stimulating hormone receptor (Fshr) or the mock plasmid and treated with various concentrations of the reference agonist. Data points shown are the mean ± SEM of an experiment (n = 4).

follicle stimulating hormone receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Mouse non-orphan GPCRs

Glycoprotein hormone receptors

Glycoprotein hormone receptors are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [1,2].


  1. Sairam MR. Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J 1989;3:1915-26.
  2. Davidson JS, Assefa D, Pawson A, et al. Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment. Biochemistry 1997;36:12881-9.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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