Mouse Prlhr

Figure. Concentration-dependent activation of Prlhr by PrRp‐31

Reporter cells were transfected with either the expression plasmid for mouse prolactin releasing hormone receptor (Prlhr) or the mock plasmid and treated with various concentrations of the reference agonist. Data points shown are the mean ± SEM of an experiment (n = 4).

Nomenclature
prolactin releasing hormone receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
Panels
à la carte, Mouse non-orphan GPCRs

Prolactin-releasing peptide receptor

The precursor (PRLH, P81277) for PrRP generates 31 and 20-amino-acid versions. QRFP43 (43RFa) (named after a pyroglutamylated arginine-phenylalanine-amide peptide) is a 43 amino acid peptide derived from href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29982">QRFP (P83859) and is also known as P518 or 26RFa. RFRP is an RF amide-related peptide [1] derived from a FMRFamide-related peptide precursor (NPVF, Q9HCQ7), which is cleaved to generate neuropeptide SF, neuropeptide RFRP-1, neuropeptide RFRP-2 and neuropeptide RFRP-3 (neuropeptide NPVF).

Reference

  1. Hinuma S, Shintani Y, Fukusumi S, et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2000;2:703-8.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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Human
PRLHR
prolactin releasing hormone receptor
Mouse
Prlhr
prolactin releasing hormone receptor