Figure. Concentration-dependent activation of PTGDR by BW245C

Reporter cells were transfected with either the expression plasmid for human prostaglandin D2 receptor (PTGDR) or the mock plasmid and treated with various concentrations of BW245C. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 380 pM.

prostaglandin D2 receptor
Available assay modes
Agonist, Inverse agonist, Antagonist, PAM, NAM
à la carte, Hematology, Human non-orphan GPCRs

Prostanoid receptors

Prostanoid receptors are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2, PGF, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [1]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.


  1. Norel X, Sugimoto Y, Ozen G, et al. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacol Rev 2020;72:910-968.
Excerpt from IUPHAR/BPS Guide to Pharmacology

Related Receptors

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