- Nomenclature
- prostaglandin E receptor 4
- Available assay modes
- Agonist, Inverse agonist, Antagonist, PAM, NAM
- Panels
- à la carte, Immunology/Infection, Oncology, Hematology, Endocrinology/Metabolism, Ophthalmology, Cardiology, Dermatology, Musculoskeletal, Urology/Reproduction, Human non-orphan GPCRs
Prostanoid receptors
Prostanoid receptors are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2, PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [1]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.Reference
- Norel X, Sugimoto Y, Ozen G, et al. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacol Rev 2020;72:910-968.
Excerpt from IUPHAR/BPS Guide to Pharmacology Related Receptors
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