- prostaglandin E receptor 1
- Available assay modes
- Agonist, Inverse agonist, Antagonist, PAM, NAM
- à la carte, Oncology, Neurology, Dermatology, Urology/Reproduction, Human non-orphan GPCRs
Prostanoid receptorsProstanoid receptors are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2, PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in . Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.
- Norel X, Sugimoto Y, Ozen G, et al. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacol Rev 2020;72:910-968.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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