Mouse Ptgdr

Prostanoid receptors

Prostanoid receptors are activated by the endogenous ligands prostaglandins PGD₂, PGE₁, PGE₂, PGF_2α, PGH₂, prostacyclin [PGI₂] and thromboxane A₂. Differences and similarities between human and rodent prostanoid receptor orthologues, and... [read more] their specific roles in pathophysiologic conditions are reviewed in [1]. Measurement of the potency of PGI₂ and thromboxane A₂ is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Reference

1. Norel X, Sugimoto Y, Ozen G, et al. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂ Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacol Rev 2020;72:910-968.

[close]