GPCR Catalog

We have all the 313 human non-sensory GPCRs in native sequences and provide functional assay for them in a single format, regardless of the subtypes of Gα proteins coupled. Click below for details.

Family

5-Hydroxytryptamine receptors

Acetylcholine receptors (muscarinic)

Adenosine receptors

Adrenoceptors

Angiotensin receptors

Apelin receptor

Bile acid receptor

Bombesin receptors

Bradykinin receptors

Calcitonin receptors

Calcium-sensing receptor

Cannabinoid receptors

Chemerin receptors

Chemokine receptors

Cholecystokinin receptors

Complement peptide receptors

Corticotropin-releasing factor receptors

Dopamine receptors

Endothelin receptors

Formylpeptide receptors

Free fatty acid receptors

GABAB receptors

Galanin receptors

Ghrelin receptor

Glucagon receptor family

Glycoprotein hormone receptors

Gonadotrophin-releasing hormone receptors

Histamine receptors

Hydroxycarboxylic acid receptors

Kisspeptin receptor

Leukotriene receptors

Lysophospholipid (LPA) receptors

Lysophospholipid (LPS) receptors

Lysophospholipid (S1P) receptors

Melanin-concentrating hormone receptors

Melanocortin receptors

Melatonin receptors

Metabotropic glutamate receptors

Motilin receptor

Neuromedin U receptors

Neuropeptide FF/neuropeptide AF receptors

Neuropeptide S receptor

Neuropeptide W/neuropeptide B receptors

Neuropeptide Y receptors

Neurotensin receptors

Opioid receptors

Orexin receptors

Orphan GPCRs

Oxoglutarate receptors

P2Y receptors

Parathyroid hormone receptors

Platelet-activating factor receptor

Prokineticin receptors

Prolactin-releasing peptide receptor

Prostanoid receptors

Proteinase-activated receptors

Proton-sensing GPCRs

QRFP receptor

Relaxin family peptide receptors

Somatostatin receptors

Steroid receptors

Succinate receptor

Tachykinin receptors

Thyrotropin-releasing hormone receptors

Trace amine receptor

Urotensin receptor

Vasopressin and oxytocin receptors

VIP and PACAP receptors

Panel

Immunology/Infection

Oncology

Hematology

Endocrinology/Metabolism

Psychiatry

Neurology

Ophthalmology

Cardiology

Respiratory

Gastrointestinal

Dermatology

Musculoskeletal

Urology/Reproduction

Non-orphan GPCRs

Orphan GPCRs

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Receptor	Family	Species	Assays
HTR1A 5-hydroxytryptamine receptor 1A	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Neurology ⋅ Gastrointestinal ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 13 nM
HTR1B 5-hydroxytryptamine receptor 1B	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Neurology ⋅ Cardiology ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 4.0 nM
HTR1D 5-hydroxytryptamine receptor 1D	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: serotonin EC50: 2.7 nM
HTR1E 5-hydroxytryptamine receptor 1E	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: serotonin EC50: 3.2 nM
HTR1F 5-hydroxytryptamine receptor 1F	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: serotonin EC50: 3.3 nM
HTR2A 5-hydroxytryptamine receptor 2A	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Respiratory ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 1.9 nM
HTR2B 5-hydroxytryptamine receptor 2B	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Cardiology ⋅ Respiratory ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 2.5 nM
HTR2C 5-hydroxytryptamine receptor 2C	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 1.7 nM
HTR4 5-hydroxytryptamine receptor 4	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Cardiology ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 26 nM
HTR5A 5-hydroxytryptamine receptor 5A	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 85 nM
HTR6 5-hydroxytryptamine receptor 6	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 8.6 nM
HTR7 5-hydroxytryptamine receptor 7	5-Hydroxytryptamine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ Non-orphan GPCRs	Reference agonist: serotonin EC50: 1.8 nM
CHRM1 cholinergic receptor muscarinic 1	Acetylcholine receptors (muscarinic)	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Neurology ⋅ Non-orphan GPCRs	Reference agonist: carbachol EC50: 310 nM
CHRM2 cholinergic receptor muscarinic 2	Acetylcholine receptors (muscarinic)	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: carbachol EC50: 110 nM
CHRM3 cholinergic receptor muscarinic 3	Acetylcholine receptors (muscarinic)	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: carbachol EC50: 31 nM
CHRM4 cholinergic receptor muscarinic 4	Acetylcholine receptors (muscarinic)	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Neurology ⋅ Non-orphan GPCRs	Reference agonist: carbachol EC50: 47 nM
CHRM5 cholinergic receptor muscarinic 5	Acetylcholine receptors (muscarinic)	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Non-orphan GPCRs	Reference agonist: carbachol EC50: 5.9 nM
ADORA1 adenosine A1 receptor	Adenosine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Neurology ⋅ Cardiology ⋅ Respiratory ⋅ Non-orphan GPCRs	Reference agonist: NECA EC50: 4.8 nM
ADORA2A adenosine A2a receptor	Adenosine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ Non-orphan GPCRs	Reference agonist: NECA EC50: 11 nM
ADORA2B adenosine A2b receptor	Adenosine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Non-orphan GPCRs	Reference agonist: NECA EC50: 19 nM
ADORA3 adenosine A3 receptor	Adenosine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Gastrointestinal ⋅ Non-orphan GPCRs	Reference agonist: NECA EC50: 1.6 nM
ADRA1A adrenoceptor alpha 1A	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: L-phenylephrine EC50: 18 nM
ADRA1B adrenoceptor alpha 1B	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Neurology ⋅ Cardiology ⋅ Non-orphan GPCRs	Reference agonist: L-phenylephrine EC50: 28 nM
ADRA1D adrenoceptor alpha 1D	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: L-phenylephrine EC50: 67 nM
ADRA2A adrenoceptor alpha 2A	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Psychiatry ⋅ Cardiology ⋅ Dermatology ⋅ Musculoskeletal ⋅ Non-orphan GPCRs	Reference agonist: noradrenaline EC50: 71 nM
ADRA2B adrenoceptor alpha 2B	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: noradrenaline EC50: 33 nM
ADRA2C adrenoceptor alpha 2C	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Cardiology ⋅ Non-orphan GPCRs	Reference agonist: noradrenaline EC50: 89 nM
ADRB1 adrenoceptor beta 1	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Endocrinology/Metabolism ⋅ Psychiatry ⋅ Cardiology ⋅ Gastrointestinal ⋅ Non-orphan GPCRs	Reference agonist: isoproterenol EC50: 22 nM
ADRB2 adrenoceptor beta 2	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: isoproterenol EC50: 26 nM
ADRB3 adrenoceptor beta 3	Adrenoceptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Endocrinology/Metabolism ⋅ Cardiology ⋅ Non-orphan GPCRs	Reference agonist: isoproterenol EC50: 47 nM
AGTR1 angiotensin II receptor type 1	Angiotensin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: angiotensin II EC50: 920 pM
APLNR apelin receptor	Apelin receptor	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Cardiology ⋅ Non-orphan GPCRs	Reference agonist: apelin-13 EC50: 8.1 nM
GPBAR1 G protein-coupled bile acid receptor 1	Bile acid receptor	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Gastrointestinal ⋅ Non-orphan GPCRs	Reference agonist: TGR5 agonist EC50: 350 nM
BRS3 bombesin receptor subtype 3	Bombesin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: bombesin EC50: 2.4 nM
GRPR gastrin releasing peptide receptor	Bombesin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Oncology ⋅ Psychiatry ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: GRP EC50: 1.3 nM
NMBR neuromedin B receptor	Bombesin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Oncology ⋅ Dermatology ⋅ Non-orphan GPCRs	Reference agonist: NMB EC50: 590 pM
CALCR calcitonin receptor	Calcitonin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: calcitonin EC50: 2.7 nM
CALCRL calcitonin receptor like receptor	Calcitonin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: CGRP EC50: 1.0 nM
CASR calcium sensing receptor	Calcium-sensing receptor	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: cinacalcet EC50: 140 nM
CNR1 cannabinoid receptor 1	Cannabinoid receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Psychiatry ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: Δ9-THC EC50: 4.1 nM
CNR2 cannabinoid receptor 2	Cannabinoid receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels:	Reference agonist: Δ9-THC EC50: 11 nM
GPR55 G protein-coupled receptor 55	Cannabinoid receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: LPI EC50: 1.2 µM
GPR119 G protein-coupled receptor 119	Cannabinoid receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Non-orphan GPCRs	Reference agonist: N-oleoylethanolamine EC50: 6.3 µM
CMKLR1 chemerin chemokine-like receptor 1	Chemerin receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: chemerin EC50: 15 nM
CCR1 C-C motif chemokine receptor 1	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Non-orphan GPCRs	Reference agonist: CCL3 EC50: 250 pM
CCR2 C-C motif chemokine receptor 2	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: CCL2 EC50: 1.3 nM
CCR4 C-C motif chemokine receptor 4	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Non-orphan GPCRs	Reference agonist: CCL22 EC50: 20 nM
CCR5 C-C motif chemokine receptor 5	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: CCL4 EC50: 7.1 nM
CCR6 C-C motif chemokine receptor 6	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ Non-orphan GPCRs	Reference agonist: CCL20 EC50: 3.8 nM
CCR7 C-C motif chemokine receptor 7	Chemokine receptors	Human	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Gastrointestinal ⋅ Dermatology ⋅ Musculoskeletal ⋅ Non-orphan GPCRs	Reference agonist: CCL21 EC50: 15 nM

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